L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER
Fmoc-Glu-OtBu
CAS: 84793-07-7
Molecular Formula: C24H27NO6
L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER - Names and Identifiers
L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER - Physico-chemical Properties
| Molecular Formula | C24H27NO6 |
| Molar Mass | 425.47 |
| Density | 1.232±0.06 g/cm3(Predicted) |
| Melting Point | 78-80 °C |
| Boling Point | 638.1±55.0 °C(Predicted) |
| pKa | 4.46±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER - Risk and Safety
| HS Code | 29224290 |
L-GLUTAMIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 1-(1,1-DIMETHYLETHYL) ESTER - Reference Information
| Use | fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl Ester is a derivative of glutamic acid 1-tert-butyl Ester, fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl ester is a basic raw material commonly used in the synthesis of polypeptides, used in the synthesis of liraglutide, thymalfasin new peptide and other drug peptides. |
| preparation | (1) glutamic acid (Glu) -5-tert-butyl glutamate (Glu(OtBu)) and glutamic acid -1-tert-butyl ester (Glu- OtBu) mixture: In a 2000ml three-neck bottle, add 581g of tert-butyl acetate and 147g of glutamic acid, stir, and add 100ml of perchloric acid Dropwise, react at 20 ℃ for 48 hours, cool down to 0 ℃, then add 600mL of water, neutralize with Na2CO3 to pH = 8~9, separate the liquid, and then wash three times with 100mL 1%Na2CO3 aqueous solution, the aqueous phases were combined and extracted three times with 200ml of petroleum ether;(2) the aqueous phase obtained in step (1) was transferred to a 2L tri-flask, and then 187.5G of CuSO4 · 5H2O was added and stirred, the pH was adjusted to 8-9 with sodium carbonate. Add 33.7 ml of tetrahydrofuran, add Fmoc-OSu g, maintain pH 8~9, react for 8 hours, prepare crude product fluorenylmethoxycarbonylglutamic acid -1-tert-butyl ester; the crude product was further acidified with HCl, extracted with ethyl acetate, concentrated to crystals under reduced pressure, filtered and dried to obtain 36g of fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl ester. The product fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl ester was analyzed by HPLC. The purity of fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl ester was 99.1%, the optical rotation was -9.4(c = 1,in HAc), the melting point was 109.5-110.6, and the isomer content was 0.03%. |
Last Update：2024-04-09 20:45:29
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Product Name: Fmoc-L-Glutamic acid 1-tert-butyl ester Visit Supplier Webpage Request for quotationCAS: 84793-07-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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